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Beitragstitel Full-field stimulus threshold testing and the relation to the oxygen metabolic retinal function in retinitis pigmentosa.
Beitragscode P27
Autor:innen
  1. Olga Maria Zabek Department of Ophthalmology, University Hospital Basel, Basel, Switzerland Präsentierende:r
  2. Giacomo Calzetti Universitätsspital Augenklinik Basel
  3. Maria della Volpe Department of Ophthalmology, University Hospital Basel, Basel, Switzerland
  4. Hendrik Scholl Universitätsspital Basel und Universität Basel
Präsentationsform ePoster
Themengebiete
  • Retina Vitreous
Abstract-Text Purpose
The aim of our study was to evaluate retinal function with (white light) dark-adapted full-field sensitivity threshold testing (FST) and find possible correlations with metabolic function measured with retinal oximetry (RO) in patients with retinitis pigmentosa (RP).

Methods
In this prospective observational study BASEC 2020-00122, FST and RO measurements were performed on 66 RP eyes (33 subjects, 12♀ 21♂) aged between 18 and 80 years (mean 43.2y). Main outcome parameters were FST thresholds using the Diagnosys Espion system with the ColorDomeTM LED full-field stimulator (Diagnosys LLC, Lowell, MA) as well as the main RO parameters: the mean arterial (A-SO2; %), venular (V-SO2; %) oxygen saturation, their difference (A-V SO2; %), and the corresponding mean diameters of the peripapillary retinal arterioles (D-A; μm) and venules (D-V; μm) recorded with the oxygen saturation tool of the Retinal Vessel Analyser (RVA; IMEDOS Systems UG, Jena, Germany). In addition, semi-automated kinetic perimetry (V4e, III4e, I4e, III3e isopters, Octopus 900®, Haag-Streit AG Bern, Switzerland) was performed and included in the ANOVA-based linear mixed-effects models analysis calculated with MATLAB®.

Results
Neither the oxygen saturation parameters A-SO2 (p=0.998), V-SO2 (p=0.595) nor the A-V SO2 (p=0.546) which represents the oxygen consumption of the retina showed significant correlations with the FST. Also, when correlated with the diameters of the peripapillary retinal arterioles (p=0.713) and venules (p=0.193) the FST showed no significant associations. However, when compared systematically with the visual field areas of the V4e, III4e, I4e, III3e-isopters, FST measures showed a significant positive correlation (p=0.028).

Conclusion
In contrast to standardized visual field parameters, white full-field sensitivity threshold testing appears not to correlate with retinal oxygen metabolic function measured with retinal oximetry in patients with RP, suggesting that the two examinations may capture unrelated aspects of the retinal pathological process. However, FST showed a significant association with standardized visual field testing parameters and may, therefore, offer an alternative outcome measure for interventional trials.